Which of the following enhances blood vessel permeability during inflammation?

• A. Adrenaline
• B. Acute phase reactants
• C. Cortisol
• D. Neuropeptides

Answer: (B)

The correct answer highlights the role of acute phase reactants in the inflammatory response, specifically in enhancing blood vessel permeability. Acute phase reactants are a group of proteins whose plasma concentrations increase in response to inflammation, typically produced by the liver. These proteins, including fibrinogen, C-reactive protein, and various cytokines, contribute to the inflammatory process by promoting various physiological changes.

One of the key functions of these reactants is to facilitate the movement of immune cells and fluid from the bloodstream into the tissue where inflammation is occurring. By increasing the permeability of blood vessels, these proteins allow for a greater influx of plasma proteins and immune cells, which is critical for the body’s ability to respond effectively to injury or infection.

This enhanced permeability aids in the formation of exudate, a protein-rich fluid that accumulates at the site of inflammation, assisting in the containment of pathogens and facilitating healing. Thus, the role of acute phase reactants is essential in modulating the inflammatory response and ensuring an appropriate defensive reaction.